Late 1980s Research Articles

Exploring Sjögren's syndrome through interdisciplinary perspectives: a concise review.

Dr. Henrik Sjögren after whom Sjögren's Syndrome is named, was a Swedish ophthalmologist who identified the syndrome which had three main symptoms namely, dry eyes, dry mouth, and arthritis. His contributions also highlighted the systemic complications of the syndrome which made our understanding of this disease better. Since then, there have been several studies on Sjögren's Syndrome (SS) of which two of them have changed the perception of the disease's prevalence. The first was a British study in the late 1990s which indicated this syndrome was no more a rare condition. The second is a 2008 study in the US which placed the syndrome as the second most prevalent autoimmune disease after rheumatoid arthritis (RA). Being one of the most prevalent autoimmune disease, there is a pressing need for a more profound and comprehensive understanding of the syndrome. This review endeavors to offer a comprehensive overview of the disease, encompassing its prevalence, manifestations, mechanisms, genetic factors, diagnostic methods, and treatment options. This review additionally offers the āyurvedic viewpoint on SS and its symptoms. This supplementary insight has the potential to contribute to the development of an integrated and holistic approach to managing the condition.

Firearm and Criminal Milieu Homicide in Sweden

This study analyzes the trend in firearm and criminal milieu–related homicides in Sweden in the past three decades. A particular focus is on the 2010–2019 period, during which a dramatic increase was noted, although an increase in firearm homicides with illegal guns had already started in the late 1990s. In extant literature, the rapid increase in the 2010s is posited to be associated with fast access to illegal weapons, especially among youth in the most urban regions, Stockholm and Skaane County in particular. As a result, many victims and perpetrators are young men. This issue is proposed to be exacerbated by the new possibilities for organized crime setups in the wake of the digital revolution, a heightened level of social problems in the aftermath of high immigration from developing countries in combination with the dismantling of welfare institutions, and a self-increasing chain reaction of violence triggered by random episodes in the criminal milieu. These hypotheses are largely supported by this study’s findings.

Borrelia burgdorferi

Since its recent discovery in the late 1970s, Lyme Disease (LD) has been a growing public health concern, especially in the United States where it accounts for the majority of vector-borne infections each year. The causative agent, Borrelia burgdorferi, is transmitted to humans through the bite of an infected Ixodes tick. This pathogen uses many unique mechanisms to both shield itself from the host immune response and cause disease. Clinically, LD presents in successive phases, with each increasing in severity as the bacterial cells migrate to new tissues and organ systems. On the epidemiological and ecological fronts, limitations in reporting, ecological changes, and a lack of public support hinder accurate surveillance and enhance the spread of the disease. The goal of this literature review is to increase public knowledge of B. burgdorferi, its vector, and the disease it causes, along with suggesting preventative measures to protect individuals who reside in high-risk areas. A collective and coordinated public health effort represents our greatest chance of restraining the LD-causing pathogen.

Balloon drift estimation and improved position estimates for radiosondes

Abstract. When comparing model output with historical radiosonde observations, it is usually assumed that a radiosonde has risen exactly above its starting point and has not been displaced by wind. This changed only relatively recently with the availability of Global Navigation Satellite System (GNSS) receivers aboard radiosondes in the late 1990s, but even then the balloon trajectory data were often not transmitted, although this information was the basis for estimating the wind in the first place. Depending on the conditions and time of year, radiosondes can sometimes drift a few hundred kilometres, particularly at the middle latitudes during the winter months. The position errors can lead to non-negligible representation errors when the corresponding observations are assimilated. This paper presents a methodology to compute changes in the balloon position during its vertical ascent, using only limited information, such as the vertical profile of wind contained in the historical observation reports. The sensitivity of the method to various parameters is investigated, such as the vertical resolution of the input data, the assumption about the vertical ascent speed of the balloon, and the departure of the surface of Earth from a sphere. The paper considers modern GNSS sonde data reports for validation, for which the full trajectory of the balloon is available, alongside the reported wind. Evaluation is also conducted by comparison with ERA5 and by conducting low-resolution data assimilation experiments. Overall, the results indicate that the trajectory of the radiosondes can be accurately reconstructed from original data of varying vertical resolutions and that the more accurate balloon position reduces representation errors and, in some cases, systematic errors.

Changes in potential evaporation with the extension of water‐saving irrigation in Xinjiang, north‐western China

AbstractSince the late 1990s, the irrigation quota in Xinjiang, northwestern China has witnessed a decline, owing to the widespread adoption of highly efficient water‐saving irrigation technologies. This phenomenon prompts the question: has there been a corresponding impact on potential evaporation? To explore changes in potential evaporation resulting from irrigation advances, we conducted a comprehensive analysis spanning the years 1978–2017 in Xinjiang. Our investigation focused on a pairwise examination of agricultural stations with substantial irrigation effects, enveloped by a substantial proportion of cultivated land, and reference stations with negligible irrigation effects, surrounded by a comparatively smaller proportion of cultivated land. The findings unveiled a noteworthy reduction in potential evaporation at agricultural stations during the period 1978–1997. However, a contrasting trend emerged in the subsequent period of 1998–2017, wherein there was a significant increase in potential evaporation. In contrast, reference stations did not exhibit statistically significant reversals in potential evaporation. The observed changes in potential evaporation at agricultural stations were primarily attributed to shifts in aerodynamic components. These changes were closely associated with the reversed changes in irrigation intensity, a consequence of the widespread adoption of water‐saving irrigation practices since 1998.

Forests high on CO2: A glimpse into how scientists study the biochemical machinery of forest ecosystems

Are forests across the planet storing more carbon as a result of rising atmospheric carbon dioxide (CO2) concentration? In this text, I propose to reflect on the work of researchers who are asking that very question. The focus is on a particular approach called free-air CO2 enrichment (FACE) experiments, in which forests in their local environment are subjected to a CO2 concentration higher than in the ambient air, to test the CO2 fertilization hypothesis. This hypothesis predicts that forests store more carbon in those conditions. FACE studies held the promise of establishing cause–effect relations and transcending the here and now. They emerged in the United States in the late 1980s, at a time when ecology scaled up to make itself relevant to the then nascent Earth System science. FACE experiments in forests are now conducted in Australia, the United Kingdom, and Brazil, and their results are closely scrutinized by a small research community. The text, first, presents the engineering feat that underpins FACE experiments in forests and discuss two problems highlighted by scientists because they impede hasty generalization from the data: the timescale needed to witness forests change and the spatial heterogeneity of forest soils. It then shows how scientists contend with their incomplete understanding of forest ecosystems as they bring together computer models and empirical data to build consensus around the sources of epistemic uncertainty. To conclude, I propose to rework the idea of “the macroscope” to conceptualize what scientists do when they seek to study forests as complex, layered, multi-scale systems. I wish to capture how researchers, who willingly endorse a planetary gaze, problematize their own predicament. This, as I suggest, has to do with the immanence of forests in the world.

Shedding light on GPIbα shedding.

Ectodomain shedding has been investigated since the late 1980s. The abundant and platelet specific GPIbα receptor is cleaved by ADAM17 resulting in the release of its ectodomain called glycocalicin. This review will address the role of glycocalicin as an end-stage marker of platelet turnover and storage lesion and will consider a potential function as effector in processes beyond hemostasis. Glycocalicin has been described as a marker for platelet senescence, turnover and storage lesion but is not routinely used in a clinical setting because its diagnostic value is nondiscriminatory. Inhibition of glycocalicin shedding improves posttransfusion recovery but little is known (yet) about potential hemostatic improvements. In physiological settings, GPIbα shedding is restricted to the intracellular GPIbα receptor subpopulation suggesting a role for shedding or glycocalicin beyond hemostasis. So far, all evidence represents glycocalicin as an end-stage biomarker of platelet senescence and a potential trigger for platelet clearance. The extensive list of interaction partners of GPIbα in fields beyond hemostasis opens new possibilities to investigate specific effector functions of glycocalicin.

Cultural globalization at sea: the rise of the modern Caribbean cruise industry

ABSTRACT Carnival, Royal Caribbean, and Norwegian—the largest cruise lines today—emerged in the late 1960s and early 1970s, advertising their packaged vacations to a growing audience of middle-class Americans interested in encountering cultural difference. This article argues that, beginning in the late 1970s and continuing into the following decade, the cultural representations that these mass-market companies leveraged drew on Eurocentric understandings of Caribbean societies, homogenizing those countries despite attempts to showcase difference. These companies also reimagined global cultures Eurocentrically in onboard themed experiences. As both a product and agent of globalization, the mass-market cruise industry selectively deployed referents in ways that increased the appeal of cruising as escapism while reducing the likelihood of cultural confusion and reassuring passengers of their comfort. Through these processes, companies produced cruise ships as metaspaces while simultaneously expanding the construction of metaspaces to ports as they gained economic and political power in the Caribbean. This process resulted in the erasure of cultural difference.

Oceanographic Research in the Thermaikos Gulf: A Review over Five Decades

The Thermaikos Gulf (TG) is a semi-enclosed, river-influenced, marine system situated in the eastern Mediterranean Sea, sustaining both urban coastal regions and ecologically preserved natural areas. Facing a plethora of environmental and anthropogenic pressures, the TG serves as a critical nexus where human activities intersect with marine ecosystems. The quality and health of the TG’s marine environment are tightly linked to the socioeconomic activities of the coastal communities comprising approximately 1.5 million inhabitants. The main features of the TG’s environmental dynamics and ecological status have been scrutinized by dedicated research endeavors during the last 50 years. This review synthesizes the seminal findings of these investigations, offering an evaluation of their contribution to research, their present collective impact, and their trajectory toward the future. A severe deterioration of the TG’s environmental quality was detected in the 1970s and 1980s when the treatment of urban wastewater was completely absent. A steady trend of recovery was observed after the 1990s; however, so far, the goal of a “good environmental state” mandated by national legislation and European directives has not been achieved. A clear reduction in research was detected after 2010, associated with the recession of the Greek economy, following the “golden period” for research in the TG from the mid-1990s until the late 2000s. The most important research gaps and uncertainties are discussed, while specific targeted recommendations for the improvement of monitoring and understanding of the physical, biochemical, and ecological state of the gulf are provided: (i) increase in permanent observational stations (temporally and spatially); (ii) inclusion of all major environmental parameters; (iii) monitoring of the quantity and quality of all land-originated freshwater discharges; (iv) monitoring and management of important aspects of the marine environment that have received minimal attention in the past (e.g., coastal erosion, plastic pollution); (v) development of accurate prediction tools (e.g., numerical techniques) to support first-level responders and efficient management; (vi) establishment of a supervising public entity that would support the holistic overview and management of the entire TG. These suggestions are directed at overcoming the existing uncertainties in the knowledge of the TG, safeguarding its ecological integrity and its role as a crucial link to marine biodiversity and sustainability in the Mediterranean basin.

Christopher Tam: Brief history and accomplishments

This introduction provides a brief personal background and highlights the scientific accomplishments of Professor Christopher Tam. He has maintained extremely high standards of research and an enviable track record for productivity, spanning more than five decades. The depth and breadth of his technical output are truly breathtaking, and he has inspired scores of researchers and graduate students. When the first author was an Acoustics Engineer at Lockheed, Georgia, he started collaborating with Chris in the early 1990s. There were several joint projects when the author moved to Boeing, which encompassed both fundamental research and applications. The second author has an even longer association with Chris, initially as a PhD advisee in the late 1980s and then as a co-researcher. In this special volume we pay tribute to Chris’s many achievements, an endeavor that provides us with great satisfaction and which is long overdue.

‘It won’t be the witches that are burning this time’: The anarchist temporalities of folk punk

This article is an exploration of the temporal politics of folk punk. Folk punk is a subgenre of punk played with predominantly acoustic instruments that emerged in the 1980s but developed a more concrete form in the late 1990s. This article compares the temporal politics of two scenes within folk punk. First, it looks at an early scene centred on the record label Plan-It-X. Second, ‘traditional folk punk’ is examined. In this latter scene, artists utilize an increasing range of instruments and musical resources associated with various types of traditional music. This musical change is also reflected lyrically; the second scene has much broader temporal references in comparison with the narrowly defined presentism of the Plan-It-X scene. The central argument of this article is that these musical and lyrical differences are politically and theoretically important. The dynamics within the folk punk scene complicate understandings of prefigurative politics, challenging the forms of presentism and individualism that this concept is associated with. The implications of these dynamics are lastly elaborated upon with reference to Gustav Landauer’s mystical anarchism.

New eusuchian cranial remains from the Upper Cretaceous of the southern Pyrenees

ABSTRACT Allodaposuchids were among the most common crocodyliforms in the Upper Cretaceous of Europe. The clade, recently erected to include a large number of species described in the last decade, seems to hold a remarkable diversity that has generated systematic controversies. Here we describe an interorbital fragment of an eusuchian crocodyliform, collected in the late 1950s in the locality of Suterranya-Mina de lignit (Lleida, Spain), from the lower Maastrichtian deposits of the Tremp Group, in the southern Pyrenees. The specimen is here identified as an allodaposuchid; some already described teeth, probably found together with the cranial remains and therefore here assigned to the same individual, reinforce this interpretation. The interorbital region of the specimen shows some important similarities with Allodaposuchus subjuniperus, reported only from the upper Maastrichtian levels of the Tremp Group, while it clearly differs from Allodaposuchus palustris, which is already reported in the lower Maastrichtian transitional deposits close to Suterranya-Mina de lignit locality. This study shows that at least three different species of allodaposuchids can be found in the lower Maastrichtian deposits of the Tremp Group.

Vitamin D: Analytical Advances, Clinical Impact, and Ongoing Debates on Health Perspectives.

Vitamin D, acknowledged since the 1930s for its role in preventing rickets, gained additional prominence in relation to fragility fracture prevention in the late 1980s. From the early 2000s, connections between vitamin D deficiency and extra-skeletal pathologies emerged, alongside increased awareness of widespread deficits. This prompted crucial debates on optimal serum concentrations, expected to conclude when the outcomes of high-dose supplementation randomized controlled trials were available. Skepticism arose with inconclusive results from these trials. This review begins with an exploration of vitamin D metabolism, followed by a detailed description of the measurement of vitamin D metabolites and the crucial role of standardization. Subsequent sections focus on the association of vitamin D with bone health and explore the extra-skeletal effects. The review concludes with a comprehensive discussion on the definition of vitamin D status and its implications for supplementation. Despite standardization efforts, assay variations and challenges still exist, especially in specific patient groups. Vitamin D supplementation has a significant impact on bone metabolism and optimal vitamin D status improves the efficacy of antiresorptive drugs such as bisphosphonates. The extra-skeletal effects of vitamin D remain debated, but may include potential benefits in conditions such as respiratory infections and cancer mortality, particularly in deficient individuals. The definition of vitamin D sufficiency is nuanced, especially when variations in population groups and analytical methods are taken into account. Despite ongoing debates and recent mega-trials tempering enthusiasm, vitamin D remains a complex and essential element in human health. Further research is needed to clarify its role in various health outcomes and guide supplementation strategies.

Resolving DAMA

The DAMA collaboration first made their claim for the detection of dark matter in the late 1990s. Since then, there have been many speculations as to the origin of their annual modulation signal and many of the hypotheses have been ruled out. At the same time, many direct detection dark matter experiments using various target medium, including those that use the same target of thallium-doped sodium iodide, have ruled out dark matter as the source of the annual modulation observed in DAMA/NaI and DAMA/LIBRA. In this paper, I will discuss the status of the ongoing efforts to resolve these conflicting observations.

Winter “warm Arctic-cold Eurasia” pattern and its statistical linkages to oceanic precursors during the era of satellite observations

AbstractA striking recurrent feature of winter climate variability is the “warm Arctic-cold Eurasia” (WACE) pattern of opposite sign anomalies of surface air temperature (SAT) in the Barents Sea region and midlatitude Eurasia. Its origins and mechanisms are hotly debated, and its predictability remains unknown. This study investigates statistical relationships of the winter WACE dipole with concurrent anomalies of atmospheric circulation and oceanic precursors during the era of satellite observations. The results reveal a high potential for seasonal predictability of not only the WACE dipole but also several related indicators of winter climate variability, including the Arctic and Eurasian SAT anomalies. During subperiods of extreme covariability between the Arctic and Eurasian SATs around the early 1980s and late 2000s, most of the WACE variability is explained by ocean temperature and surface turbulent heat flux anomalies in the Barents Sea region during the preceding months. Anomalies in summer Atlantic water temperature (AWT) and autumnal sea surface temperature (SST) in this region explain about 70–80% of the variance of the following winter WACE variability during all events of strong Arctic-Eurasian SAT covariability. Analysis of SST variability in the Arctic-North Atlantic region suggests that the winter WACE link to the summer AWT anomalies reflects an atmospheric response to a large-scale surface reemergence of ocean temperature anomalies. However, this linkage had been robust only until the early 2000s. Since then, the winter WACE variability has been strongly related to autumnal SST anomalies in the Barents Sea region and the North Pacific.

The <i>Krabat</i> Motif in the Songs and Musicals of <i>Liedermacher</i> Gerhard Gundermann

This article looks at Gerhard Gundermann’s use of the Krabat motif from Jurij Brězan’s novel Krabat or the Transformation of the World in his Liedertheater productions with Brigade Feuerstein in the GDR and, post-unification, in his solo songs. From Hoyerswerda in South-East Germany, Gundermann was simultaneously an open-cast miner and a singer/songwriter and dramatist who died prematurely in 1998 at the age of 43. Emerging out of the GDR singing club movement in the late 1970s, he relentlessly exposed the ruling SED Party’s monopoly on power in his work with Brigade Feuerstein. After German unification, as a solo performer, he became the mouthpiece of culturally disenfranchised East Germans. Twenty-five years after his death—in the wake of renewed interest in this performer as evidenced by Andreas Dresen’s film Gundermann (2018) and Grit Lemke’s documentary Gundermann Revier (2019)—it is time for a proper academic assessment of his work. This study breaks new ground, firstly in its analysis of the unpublished works of Brigade Feuerstein and secondly by exploring the extent to which Gundermann’s life work was underpinned by the philosophy of Krabat, in its exposing of humans’ exploitation of one another and their environment. In this, one can see how Gundermann created an aesthetic approach that successfully spanned two political systems.

An Analysis of Holistic Education Models in Mainland China’s Higher Education Institutions: A Case Study of College English Curriculum

Over the last four decades, the field of education in mainland China has seen sustained and stable growth. However, the very essence of education has undergone significant changes. In the era spanning from the 1980s to the mid-1990s, the primary aim of education was to serve economic construction and modern development, with a clear emphasis on utilitarian and instrumental characteristics. By the late 1990s, there was a shift towards advocating for quality education that prioritizes the comprehensive development of individuals, gradually embracing the concept of holistic education across the Chinese mainland. College English courses, mandatory for all non-English major undergraduates at Chinese universities, stand as a pivotal component of general education. Amidst the extensive backdrop of educational reform and development in mainland China, college English curriculum have experienced profound changes. The “College English Curriculum Guidelines (2020)” recently released by the Ministry of Education highlights that college English courses possess both instrumental and humanistic dimensions. The instrumental aspect is demonstrated through enhancing students’ comprehensive abilities in listening, speaking, reading, writing, and translating English, while its humanistic core is rooted in a people-oriented approach that celebrates human values and emphasizes the cultivation of comprehensive qualities and overall development. This paper aims to explore the practical model of implementing holistic education within college English curriculum, adhering to the specific requirements of the 2020 guidelines, across four dimensions: curriculum system, instructional approaches, educational resources, and faculty strength.

Wakanda forever! Consistency in correlates of black nationalist tendencies

Wakanda forever! Consistency in correlates of black nationalist tendencies

Transitional Justice in Albania, Kosovo, and North Macedonia in a Comparative Framework

This thesis aims to enhance transitional justice studies with a focus on the Balkan peninsula, by providing a comparative analysis of the extent of transitional justice mechanisms in Albania, Kosovo, and North Macedonia. With the fall of military dictatorships in Latin America in the 1980s, the breakup of the Soviet Union, and the emergence of new states in the 1990s, the concept of Transitional Justice (TJ) saw a significant rise in the late 1980s and early 1990s. This was further propelled by the fall of the Berlin Wall (1989), the prolonged breakup of the Socialist Federal Republic of Yugoslavia (1992) as well as the fall of the communist dictatorship in Albania (1990). The emergence of new states and the state-building processes that followed the political and social changes also brought new challenges and conflicts, although they marked the end of significantly repressive political regimes. Considering that the implementation of TJ has undergone several changes over time and is dependent on the different settings in which it was employed, it is necessary to conduct extensive comparative research to determine the extent to which TJ differs in post-communist and post-conflict nations. The study has developed three main hypotheses: (1) The limited achievement of lustration law in Albania has conditioned the current status of transitional justice; (2) The state-building process has contributed to the evolution of Transitional Justice in Kosovo; (3) The power-sharing process as a TJ pillar in North Macedonia has fueled TJ in the country. By utilizing a mixed methods approach, data was collected through elite interviews, conducted in the three countries with 44 representatives from academia, politics, media, and civil society. To conclude, two hypotheses are fully upheld in terms of the limited achievement of lustration law and its implications with the current status of transitional justice in Albania; and the contribution of state-building in Kosovo to the evolution of transitional justice. The third hypothesis related to the power-sharing process in North Macedonia as a fueling mechanism for the evolution of transitional justice is partially upheld.    Received: 13 February 2024 / Accepted: 30 April 2024 / Published: 5 May 2024

2 Another renaissance for bile acid gastrointestinal microbiology

Abstract The field of bile acid microbiology in the gastrointestinal tract is going through a current rebirth after a peak of activity in the late 1970s and early 1980s. This renewed activity is a result of many factors including the discovery near the turn of the century that bile acids are potent signaling molecules, technological advances in next generation sequencing, computation, culturomics, gnotobiology, and metabolomics. The current state of the field with particular emphasis on questions that have remained unanswered for many decades in both bile acid synthesis by the host, and metabolism by the gut microbiota will be addressed. Current knowledge of established enzymatic pathways including bile salt hydrolase, hydroxysteroid dehydrogenases involved in the oxidation and epimerization of bile acid hydroxy groups, the Hylemon-Bjӧrkhem Pathway (HBP) of bile acid C7-dehydroxylation, and the formation of secondary allo-bile acids are described. Aspects of bile acid conjugation and esterification, and evidence for bile acid C3- and C12-dehydroxylation that are less well understood, but potentially critical for our understanding of bile acid metabolism in the human gut will be covered. The physiological consequences of bile acid metabolism for human health, important caveats and cautionary notes on experimental design and interpretation of bile acid metabolism are also explored.